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99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass

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99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass

China 99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass supplier
99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass supplier 99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass supplier 99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass supplier 99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass supplier

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Product Details:

Place of Origin: CHINA
Brand Name: Aicar
Certification: ISO 9001 ; USP ; GMP ; HSE
Model Number: 2627-69-2

Payment & Shipping Terms:

Minimum Order Quantity: 10grm
Price: Negotiation
Packaging Details: Discreet and Safe Packages for Safe Shipping
Delivery Time: in 24 hours
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin,Credit card
Supply Ability: in stock
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Detailed Product Description
Name: Aicar CAS: 2627-69-2
Payment Terms: Money Gram, Western Union, Bank Transfer,Bitcoin,Credit Card Purity: 99%
Appearance: White Powder MF: C9H14N4O5
Brand: Bodybiological Email: Daisy_doublewin@foxmail.com
High Light: Bodybuilding Legal Steroids, Fat Burning Sarms

99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass

 

 

Product Details

Other name: Acadesine,AICAR,AICA-RIBOSIDE,AMPK,Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 99%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

 

Aicar is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with Aicar mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

 

 

Function

 

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

 

COA

Item
Specification

Result

Appearance


White powder

Complies

Related substance (HPLC)

Total impurity ≤0.5%
Max single impurity ≤0.1%

0.2%
0.06%

Odor

Characteristic

Complies

Assay

99%

99.8%

Sieve analysis

100% pass 80 mesh

Complies

Loss on Drying
Residue on Ignition

≤1.0%
≤1.0%

0.12%
0.09%

Heavy Metal

<10ppm

Complies

As

<0.1ppm

0.05ppm

Pb

<0.1ppm

0.05ppm

Cd

<0.1ppm

0.05ppm

Residual Solvents

<100ppm

Complies

Residual Pesticide

Negative

Complies

Microbiology
   

Total Plate Count

<1000cfu/g

Complies

Yeast & Mold

<100cfu/g

Complies

E.Coli

Negative

Complies

Salmonella

Negative

Complies

 

 

Application


Aicar (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR& alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.
Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).
The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

99% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass 099% Purity CAS 2627-69-2 SARMs Raw Powder Aicar Acadesine For Muscle Mass 1

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